IL-10 Up-Regulates Macrophage Expression of the S100 Protein S100A8

Il-10 up-regulates macrophage expression of the S100 protein S100A8.

The murine calcium binding protein S100A8 (A8) is a leukocyte chemoattractant, but high levels may be protective and scavenge hypochlorite. A8 is induced by LPS, IFN-gamma, and TNF in elicited macrophages. Th2 cytokines generally suppress proinflammatory gene expression, and IL-4 and IL-13 partially decreased A8 induction in macrophages and endothelial cells stimulated by LPS or IFN. In contras...

IL-10 Up-Regulates Macrophage Expression

S 100 Protein S 100 A 8 IL - 10 Up - Regulates Macrophage Expression

This information is current as of the S 100 Protein S 100 A 8 IL - 10 Up - Regulates Macrophage Expression

Oxidation regulates the inflammatory properties of the murine S100 protein S100A8.

The myeloid cell-derived calcium-binding murine protein, S100A8, is secreted to act as a chemotactic factor at picomolar concentrations, stimulating recruitment of myeloid cells to inflammatory sites. S100A8 may be exposed to oxygen metabolites, particularly hypochlorite, the major oxidant generated by activated neutrophils at inflammatory sites. Here we show that hypochlorite oxidizes the sing...